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Dicorate ER 250 Mg


Generic:              Divalproex
Manufacturer:   Sun Pharmaceutical Industries Ltd
Pack size:          30 Tablet/s, 60 Tablet/s, 90 Tablet/s    
Pharma Form:   Tablet
Strength:            250 mg
Uses:                  Anti Migraine Drugs

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What is dicorate ER 250 mg? 

Dicorate ER 250 mg is a highly popular medication used to manage various neurological and psychiatric conditions, thanks to its active ingredient divalproex sodium. Divalproex sodium is composed of two compounds: sodium valproate and valproic acid, both of which contribute to its therapeutic effects. Dicorate ER 250 mg can often be prescribed for treating epilepsy, bipolar disorder, migraines, etc.

Active Ingredient: Divalproex Sodium

Divalproex sodium is an active ingredient that converts to valproic acid within the body, with this action believed to increase GABA (gamma-aminobutyric acid), an inhibitory neurotransmitter found throughout the brain that modulates GABA levels to bring anticonvulsant and mood-stabilizing effects to its user. By modulating these GABA levels, divalproex sodium provides anticonvulsant and mood-stabilizing benefits simultaneously.

Indications and Clinical Applications

Doctors can prescribe Dicorate ER 250 mg to treat various neurological and psychiatric conditions.

1. Epilepsy:It serves as an anticonvulsant to manage seizures in individuals living with epilepsy.

  1. Dicorate ER helps control manic and depressive episodes associated with bipolar disorder.

  2. Dicorate ER can help prevent migraine headaches in certain individuals for migraine prophylaxis.

 Mechanism of Action

 While the precise mechanism of divalproex sodium's action remains unknown, it appears to have multiple effects:

1 GABAergic Modulation: Divalproex sodium may increase GABA levels in the brain and thus enhance inhibitory neurotransmission.

  1. Inhibition of Voltage-Gated Sodium Channels: Divalproex sodium may block voltage-gated sodium channels to stabilize neuronal membranes and lower abnormal electrical activity. This may stabilize neuronal membranes as a whole and lower abnormal electrical activity.

  2. Calcium Channel Modulation: Additionally, Divalproex sodium has the ability to modulate calcium channels for more precise neurotransmitter release.

Dosage and Administration

Dicorate ER 250 mg dosage is determined by healthcare providers according to the specific condition being treated, patient age, and individual responses to medication. Its extended release formula was specifically created to allow once-daily dosing with optimal therapeutic levels in mind. Adherence is crucial to this medication's therapeutic efficacy in maintaining therapeutic levels within the body.

Side Effects and Considerations

Dicorate ER 250 mg may cause side effects, including drowsiness, dizziness, and gastrointestinal symptoms. Serious but rare side effects could include liver toxicity or pancreatitis; therefore, regular monitoring of liver function as well as adhering to healthcare provider recommendations are imperative for optimal care.

Precautions and Special Considerations

Administer Dicorate ER 250 mg to certain populations with special consideration:

  1. Pregnancy and Breastfeeding: The use of divalproex sodium during gestation is linked with an increased risk of birth defects, so pregnant and breastfeeding individuals should consult their healthcare provider about alternative medications as soon as possible.

  2. Monitor individuals with a history of liver disease or impaired liver function carefully.

  3. Children: Dicorate ER 250 mg should only be administered to children after careful consideration has been given to the age and weight of each individual child.

Individualized treatment and regular monitoring

Healthcare providers regularly monitor treatment response, side effects, and make necessary changes that contribute to the success of Dicorate ER 250 mg treatment plans tailored specifically to each neurological or psychiatric condition being addressed.

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