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Co-Trimoxazole Tablet


Generic:              Sulfamethoxazole / Trimethoprim
Manufacturer:   Omega Pharma
Pack size:          30 Tablet/s, 60 Tablet/s, 90 Tablet/s    
Pharma Form:   Tablet
Strength:            400 Mg and 80 Mg
Uses:                  Antibiotics

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Categories: Antibiotics
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What is a Co-Trimoxazole Tablet? 


Co-Trimoxazole, also known as Trimethoprim/Sulfamethoxazole, is a versatile combination antibiotic medication commonly prescribed for the treatment of various bacterial infections. It consists of two active ingredients, trimethoprim and sulfamethoxazole, that work against a wide variety of microbes, making this combination antibiotic treatment versatile in treating various kinds of infections. 


Mechanism of Action 


Trimethoprim: This component inhibits dihydrofolate reductase, an enzyme required for producing tetrahydrofolic acid, an essential precursor for DNA and RNA synthesis in bacteria, thus interfering with their replication and growth. By blocking this step, trimethoprim has an impactful antimicrobial action against infections such as influenza. 


  1. Sulfamethoxazole is a sulfa drug that stops dihydropteroate synthetase from working. This enzyme helps bacteria make folic acid, which they use to make nucleic acids and proteins. By stopping this enzyme from working, the bacteria can't multiply. By disabling its production, sulfamethoxazole hinders this multiplication. 


Co-Trimoxazole's combination of trimethoprim and sulfamethoxazole produces a synergistic effect, increasing antibacterial activity overall. It's typically prescribed to treat various bacterial infections, including: 




  1. Urinary Tract Infections (UTIs): Co-Trimoxazole can effectively treat both uncomplicated and complex UTIs caused by bacteria that are susceptible. 


  1. Co-Trimoxazole can treat respiratory tract infections such as bronchitis and pneumonia. 


  1. 3. Gastrointestinal Infections: Co-Trimoxazole can be prescribed to treat certain strains of gastroenteritis caused by bacteria to which it is susceptible. 4. Skin and Soft Tissue Infections: Co-Trimoxazole can also help combat certain skin infections, cellulitis, and wound infections. 


Dosage and Administration: 


Co-Trimoxazole dosage depends on the specifics and severity of the infection being treated. It should be taken orally with water; for optimal effectiveness, it should complete its course despite improvement before completion has taken place to prevent antibiotic resistance and maintain effectiveness. 


Monitoring and side effects 


 Patients taking co-trimoxazole should be closely monitored for potential side effects. Common adverse reactions may include nausea, vomiting, diarrhoea, and allergic reactions, while more serious effects such as blood disorders, kidney issues, or severe skin reactions (although rare) should also be watched out for during long-term usage of Co-Trimoxazole. Regular blood counts or kidney function monitoring are advised during prolonged use. 


Precautions and Considerations 


Nonetheless, it should also be remembered to take the necessary precautions. Precautions and Considerations: Before prescribing Co-Trimoxazole, it should also take precautions and considerations into account. 


Allergies: Patients who have known allergies to sulfa drugs or related medications should inform their healthcare provider immediately. 


During pregnancy, especially in the first trimester, caution should be exercised when using Co-Trimoxazole due to its potential excretion into breast milk. 


Renal Impairment: Individuals with impaired kidney function may require adjustments in dosage to remain effective. 

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